Officials say the towns of Accumoli and Amatrice appear to be the hardest hit by the quake, which struck at 3:36 a.m. local time as most residents slept inside their homes.

At least 10 people have been killed, according to the Associated Press.

The damage was so extensive in the town of Amatrice that its mayor told the AP: "The town isn't here anymore."

Tremors were felt as far away as Rome, more than 100 miles away from the quake's epicenter.

The mayor of Amatrice told Italy's ANSA news agency that a large portion of that town had been destroyed and that residents had been buried under the rubble of collapsed homes and buildings.

Sergio Pirozzi told state-run RAI radio and Sky TG24 that he needs heavy equipment to clear rubble-clogged streets to get to the injured, the Associated Press reported.

Asked if there were any dead he said: "Look there are houses that aren't here anymore. I hope we get some help," according to the AP.

The mayor of the nearby town of Accumoli reported one family of four found under debris with no apparent signs of life, as well as one other possible victim.

Fabio Curcio, head of Italy's Civil Protection Department, called it a “serious earthquake” that resulted in "wounded" and “serious damage,” ANSA reported.

The Civil Protection Department labeled the earthquake as "severe," as reports of power and communications outages and ruptured gas lines added to the difficulties facing emergency responders.

The quake was felt across four regions of central Italy: Lazio, Umbria, Abruzzo and Marche.

The U.S. State Dept. urged Americans in the area to contact their loved ones.

The United States Geological Survey (USGS) confirmed the quake's location and its magnitude.

The central Apennine region, a mountainous area of central Italy, has seen several significant temblors in the past, according to the USGS.

In April 2009, 6.3 magnitude quake near the town of L’Aquila killed at least 295, injured over 1,000 and left at least 55,000 homeless.

In September 1997, a 6.0 magnitude earthquake in the area killed 11 and injured over 100, destroying approximately 80,000 homes in the Marche and Umbria regions.

On January 13, 1915, a magnitude 6.7 earthquake near Avezzano killed approximately 32,000 people.

The Associated Press contributed to this report.

Source: AP